医学
甲状腺机能正常
内科学
内分泌学
左旋甲状腺素
甲状腺功能
亚临床感染
体质指数
三碘甲状腺素
甲状腺过氧化物酶
甲状腺功能测试
抗甲状腺自身抗体
甲状腺
抗体
自身抗体
免疫学
作者
Marina Michalaki,Apostolos G. Vagenakis,Aggeliki Leonardou,Maria-Ioanna Argentou,Ioannis Habeos,Maria Makri,Agathoklis Psyrogiannis,Fotis Kalfarentzos,Venetsana Kyriazopoulou
出处
期刊:Thyroid
[Mary Ann Liebert]
日期:2006-01-01
卷期号:16 (1): 73-78
被引量:233
标识
DOI:10.1089/thy.2006.16.73
摘要
Morbidly obese subjects may present with abnormal thyroid function tests but the reported data are scarce. Therefore, we studied the thyroid parameters in 144 morbidly obese patients, 110 females and 34 males, to assess the prevalence of hypothyroidism. Eleven percent (11.8%) carried the diagnosis of hypothyroidism and were undergoing levothyroxine (LT4) replacement therapy, 7.7% had newly diagnosed subclinical hypothyroidism, 0.7% had subclinical hyperthyroidism and 7.7% were euthyroid with positive antibodies (anti-thyroid peroxidase antibodies [TPOAb]). From the 144 subjects, we selected a cohort of 78 euthyroid subjects with negative TPOAb, who did not receive LT4 replacement or suppression therapy (the experimental group) and compared them to 77 normal-weight euthyroid subjects, TPOA-negative, matched for age and gender who served as controls. The experimental group had higher serum levels of triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), and thyrotropin (TSH) compared to the control group. Serum TSH concentration was associated with fasting serum insulin levels and insulin resistance but not with serum leptin levels, body mass index (BMI), fat mass, and lean body mass. In conclusion, in morbidly obese individuals, the prevalence of overt and subclinical hypothyroidism was high (19.5%). The morbidly obese subjects have higher levels of T3, FT3, T4, and TSH, probably the result of the reset of their central thyrostat at higher level.
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