免疫学
免疫系统
生物
先天免疫系统
先天性淋巴细胞
发病机制
分泌物
白细胞介素
细胞因子
细胞生物学
内分泌学
作者
Stefanie Eyerich,Kilian Eyerich,Andrea Cavani,Carsten B. Schmidt‐Weber
标识
DOI:10.1016/j.it.2010.06.004
摘要
T helper (Th) cell subsets secrete cytokines that regulate other immune cells. Interleukin (IL)-17 and IL-22 belong to a new class of cytokines with predominant effects on epithelial cells. Thus, these cytokines are key molecules in several disease processes. IL-17 and IL-22 are released by leukocytes such as Th and natural killer cell populations. Both IL-17 and IL-22 induce an innate immune response in epithelial cells, but their functional spectra are generally distinct. IL-17 induces an inflammatory tissue response and is involved in the pathogenesis of several autoimmune diseases, whereas IL-22 is protective/regenerative. This review juxtaposes IL-17 and IL-22 and describes overlaps and differences regarding their cellular sources, biochemical structure, signaling cascades in target cells, and function.
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