ANTIRADIATION EFFECTIVENESS OF CYSTAMINE UNDER VARYING CONDITIONS OF GAMMA IRRADIATION.

When cystamine is administered intraperitoneally to mice 5 to 10 minutes prior to gamma-irradiation (139 - 159 r/min), there is a linear dependence of the dose reduction factor (DRF) on the cystamine dose. The increase in the administration time of the preparation at 15 mg/kg to 30 minutes prior to irradiation does not have a significant influence on its protective properties. One hour later, the antiradiation activity of the protector decreases sharply. When cystamine was used in doses of 50 to 100 mg/kg, the decrease in the protector protective properties was noticed at earlier stages. With irradiation for 1.5 to 4 hours, the protective activity of cystamine, AET, tsistafos and 5-MOT decreased sharply.