Progress in the mechanisms of somatic cells reprogramming induced by cell fusion

Differentiated somatic cells can dedifferentiate into pluripotent state by reprogramming,which makes great sense in cell transplantation,disease modeling as well as drug screening.Cell fusion between somatic cells and stem cells can reprogram somatic cells quickly and efficiently,which is an important means to explore the mechanisms of cell reprogramming.In this paper,we summarize the recent advances in cell fusion methods and the mechanisms of somatic cells reprogramming by cell fusion.