The Effect of Allogeneic Transfusion on Polarized Th cell in Gastric Carcinoma Patients during Perioperative Time

Objective: To study the effects of allogeneic blood transfusion on polarized Th cell in gastric carcinoma patients during perioperative time. Methods: Thirty patients undergoing gastric carcinectomy were randomly divided into three groups with 10 patients in each group: group A received no allogeneic blood; group B received leukodepleted blood; group C received allogeneic whole blood during perioperative time. The polarized rates of Th cell were measured by flow cytometry. Results: The counts of Th1 in group A decreased significantly on the 2nd postoperation, but returned to the baseline levels on the 5th postoperative day. The Th1 counts and Th1/Th2 ratio decreased significantly in group B and group C after blood transfusion(P0.05). The Th2 counts increased significantly in group B and C postoperative time. On the 10th postoperative day the Th1?Th2 cell counts and Th1/Th2 ratio returned to preoperative level in group B, but remained low in group C. As compared with that in group A, the Th1 cell counts, Th1/Th2 ratio reduced and Th2 cell counts increased markedly in group C than in group B(P0.05). Conclusion: Perioperative blood transfusion contributes to the immunosuppression, which is more serious after whole blood transfusion than leukodepleted blood. In perioperative period component blood transfusion is superior to whole blood transfusion. The Th cells polarized to Th2 cells may be one of the causes of immunosuppression in patients received allogeneic blood transfusion.