Candida is a major pathogen responsible for deep fungal infections.The extensive use of antifungal agents has resulted in Candida having serious resistance to these antifungal drugs.This review describes advances in the study of the mechanisms by which Candida develops resistance to commonly used antifungal agents such as azoles,polyenes,and echinocandins in order to provide a theoretical basis for further research on the mechanism of Candida's drug resistance and to guide the rational use of antifungal agents.