转运蛋白
小胶质细胞
神经炎症
活性氧
神经科学
NADPH氧化酶
平衡
功能(生物学)
细胞生物学
化学
生物
免疫学
炎症
作者
Tomás R. Guilarte,Meredith K. Loth,Sara R. Guariglia
标识
DOI:10.1016/j.tips.2016.02.008
摘要
During the past decade, translocator protein 18 kDa (TSPO), previously named peripheral benzodiazepine receptor, has gained a great deal of attention based on its use as a clinical biomarker of neuroinflammation with therapeutic potential. However, there is a paucity of knowledge on the function(s) of TSPO in glial cells. Here, we identify a novel function of TSPO in microglia that is not associated with steroidogenesis. We propose that a TSPO interaction with NADPH oxidase (NOX2) links the generation of reactive oxygen species (ROS) to the induction of an antioxidant response to maintain redox homeostasis. This line of investigation may provide a greater understanding of TSPO glial cell biology, and the knowledge gained may prove beneficial in devising therapeutic strategies.
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