Efficacy of Piperacillin/Tazobactam versus Ciprofloxacin plus Metronidazole for Complicated Intraabdominal Infection

OBJECTIVE:To evaluate the efficacy of Piperacillin/Tazobactam versus Ciprofloxacin plus Metronidazole for complicated intraabdominal infection. METHODS: 192 patients whose bacterial culture test on intraoperative-resected samples indicated growth of at least one pathogen were treated with Piperacillin/Tazobactam versus Ciprofloxacin plus Metronidazole for complicated intraabdominal infection. The drug resistance of the pathogens isolated form intraoperative-resected samples and the parameters including the clinical effective rate etc were compared between the two groups excluding the resistant cases. RESULTS: 85 case received Piperacillin/Tazobactam versus 107 cases received Ciprofloxacin plus Metronidazole,and the resistance rates of the pathogens isolated from the intraoperative-resected samples were 5.9% (5/85) and 21.5% (23/107),respectively. The clinical effective rates in the two groups excluding the resistant cases were 92.5% (74/80) and 77.4%(65/84),respectively,showing significant difference (P0.05). CONCLUSION: Whether being used as empiric drug or confirmed drug for complicated intraabdominal infection,the efficacy of Piperacillin/Tazobactam is significantly superior to Ciprofloxacin plus Metronidazole,thus Piperacillin/Tazobactam should be used as the first line therapy for complicated intraabdominal infection.