Objective: To study the antioxidant effect of selenium,jinchuan health beer and the combination of selenium and beer in mice with tumor.Methods: the mice were fed with selenium,beer and the combination of selenium and beer,we decided antioxidant effect by determining the serum malondialdehyde(MDA),liver superoxide dismutase(SOD),lactate dehydrogenase(LDH).Results: the serum malondialdehyde(MDA) and lactate dehydrogenase(LDH) in Se group,beer group and the combination of selenium and beer group were significantly lower than those of the control group(P0.05).The liver superoxide dismutase(SOD) in group Se,beer and the combination of selenium and beer was higher than that of the control group(P0.01).Conclusion: Selenium,beer and the combination of selenium and beer shows good antioxidant effect,reduce the lactate dehydrogenase(LDH) in vivo.