The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer

免疫编辑 癌症免疫疗法 免疫疗法 癌症 免疫系统 免疫 免疫学 医学 癌症疫苗 抗原 生物 癌症研究 内科学
作者
Jeffrey P. Ward,Matthew M. Gubin,Robert D. Schreiber
出处
期刊:Advances in Immunology 卷期号:: 25-74 被引量:164
标识
DOI:10.1016/bs.ai.2016.01.001
摘要

Definitive experimental evidence from mouse cancer models and strong correlative clinical data gave rise to the Cancer Immunoediting concept that explains the dual host-protective and tumor-promoting actions of immunity on developing cancers. Tumor-specific neoantigens can serve as targets of spontaneously arising adaptive immunity to cancer and thereby determine the ultimate fate of developing tumors. Tumor-specific neoantigens can also function as optimal targets of cancer immunotherapy against established tumors. These antigens are derived from nonsynonymous mutations that occur during cellular transformation and, because they are foreign to the host genome, are not subject to central tolerance. In this review, we summarize the experimental evidence indicating that cancer neoantigens are the source of both spontaneously occurring and therapeutically induced immune responses against cancer. We also review the advances in genomics, bioinformatics, and cancer immunotherapy that have facilitated identification of neoantigens and have moved personalized cancer immunotherapies into clinical trials, with the promise of providing more specific, safer, more effective, and perhaps even more generalizable treatments to cancer patients than current immunotherapies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
曾义准完成签到,获得积分10
刚刚
无聊的完成签到,获得积分10
2秒前
华仔应助枫叶-ZqqC采纳,获得10
3秒前
慕青应助z张z采纳,获得10
4秒前
炜博完成签到,获得积分10
5秒前
萤火虫发布了新的文献求助10
6秒前
7秒前
顾矜应助小仙女采纳,获得10
7秒前
8秒前
ljj001ljj发布了新的文献求助10
12秒前
12秒前
13秒前
16秒前
小仙女完成签到,获得积分10
17秒前
17秒前
萤火虫完成签到,获得积分10
18秒前
小仙女发布了新的文献求助10
19秒前
萤火虫发布了新的文献求助10
21秒前
枫叶-ZqqC发布了新的文献求助10
21秒前
EurekaOvo完成签到,获得积分10
31秒前
李爱国应助Fishie采纳,获得10
35秒前
研友_VZG7GZ应助哇塞漂亮采纳,获得10
35秒前
chenn完成签到 ,获得积分10
35秒前
35秒前
shinysparrow应助邹123采纳,获得10
38秒前
领导范儿应助科研通管家采纳,获得10
40秒前
深情安青应助科研通管家采纳,获得10
40秒前
研友_VZG7GZ应助科研通管家采纳,获得10
40秒前
张大宝完成签到 ,获得积分10
43秒前
44秒前
Owen应助吉祥财子采纳,获得10
47秒前
49秒前
向日葵发布了新的文献求助10
50秒前
桐桐应助爱听歌雪旋采纳,获得10
53秒前
lkm完成签到,获得积分10
56秒前
搜集达人应助cctv18采纳,获得10
57秒前
cctv18给复杂的如彤的求助进行了留言
1分钟前
1分钟前
1分钟前
1分钟前
高分求助中
Teaching Social and Emotional Learning in Physical Education 900
Plesiosaur extinction cycles; events that mark the beginning, middle and end of the Cretaceous 800
Recherches Ethnographiques sue les Yao dans la Chine du Sud 500
Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism 500
Chinese-English Translation Lexicon Version 3.0 500
[Lambert-Eaton syndrome without calcium channel autoantibodies] 440
Wisdom, Gods and Literature Studies in Assyriology in Honour of W. G. Lambert 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2389737
求助须知:如何正确求助?哪些是违规求助? 2095752
关于积分的说明 5278773
捐赠科研通 1822898
什么是DOI,文献DOI怎么找? 909318
版权声明 559593
科研通“疑难数据库(出版商)”最低求助积分说明 485920