Prospective Comparison of 64Copper [64Cu]SAR-bisPSMA vs 68Gallium[68Ga] PSMA-11 PET/CT for Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy (Co-PSMA Trial)

BACKGROUND AND OBJECTIVE: Ga-PSMA) in BCR post radical prostatectomy (RP) (NCT06907641). METHODS: Cu-bisPSMA). The primary endpoint was mean per-participant lesional difference. Paired t tests and mixed-effects Poisson regression assessed lesion number differences between scans. KEY FINDINGS AND LIMITATIONS: Ga-PSMA, respectively. CONCLUSION AND CLINICAL IMPLICATIONS: Ga PSMA-PET/CT with substantial management impact and a high RS true positive rate in men with BCR post RP.