OGT regulates histone demethylation and alleviates osteoarthritis progression by O-GlcNAcylation of KDM6B

OGT is a key regulator of OA that exerts its function by modulating the epigenetic state of chondrocytes. Loss of OGT in chondrocytes not only disrupts normal cartilage development but also accelerates OA progression under pathological conditions, thereby providing new experimental evidence for understanding OA pathogenesis and informing the development of potential therapeutic strategies.