Schaftoside ameliorates MCD diet-induced nonalcoholic steatohepatitis via modulating immune microenvironment

In summary, our study provides the first evidence that SS exerts anti-NASH effects by orchestrating immune cell functions, particularly through macrophage polarization and dendritic cell modulation, thereby rectifying the dysregulated immune microenvironment. These findings position SS as a promising candidate for novel NASH therapies.