Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis

Our findings demonstrate that Biochanin A alleviates endothelial and vascular senescence by targeting the HDAC1/H3K4me3/NFKB1 axis. This epigenetic mechanism inhibits NF-κB-mediated SASP production, positioning BCA as a promising natural epigenetic modulator to restore vascular homeostasis and mitigate age-related vascular dysfunction.