Using an integrated formula-disassembled strategy and PK-PD analysis, we systematically deciphered LHQW's compatibility principle: YQP, MXSGD, and Dahuang exert distinct therapeutic effects and synergistic mechanisms; intact LHQW's optimized component exposure underpins its holistic efficacy. These findings provide mechanistic evidence for LHQW's formula design, highlighting the scientific intelligence of integrating classical and modern medical principles.