传统医学
生药学
生物碱
生物
化学
植物
医学
生物活性
生物化学
体外
作者
M D Li,Xinlin Chen,Zhanpeng Yu,Yalin Li,Liang Hong,Yu-Xing Cai,Ling‐Yi Kong,Jian‐Guang Luo
出处
期刊:Fitoterapia
[Elsevier]
日期:2024-01-01
卷期号:: 105843-105843
标识
DOI:10.1016/j.fitote.2024.105843
摘要
In this research, five new indolequinazoline alkaloids (1–5), along with six known indolequinazoline alkaloids (6–11) were obtained from the fruits of Tetradium ruticarpum. Their structures were elucidated through comprehensive spectroscopic data of 1D and 2D NMR, HRESIMS and ECD spectra. Additionally, all isolates were assayed for their SIRT1 inhibitory activities in vitro and compounds 2, 7, 10 and 11 exhibited activities with IC50 values ranged from 43.16 to 118.35 μM.
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