壳聚糖
表征(材料科学)
低聚糖
甲壳素
化学
生物医学
广谱
化学改性
组合化学
纳米技术
生化工程
生物化学
材料科学
有机化学
生物信息学
生物
工程类
作者
Bing Li,Jing-Chun Cui,Ting Xu,Yan Xu,M. Long,Jiaqi Li,M. Liu,Tao Yang,Yuguang Du,Qingsong Xu
标识
DOI:10.1016/j.carbpol.2024.121914
摘要
Chitosan oligosaccharide (COS), which represent the positively charged basic amino oligosaccharide in nature, is the deacetylated and degraded products of chitin. COS has become the focus of intensive scientific investigation, with a growing body of practical and clinical studies highlighting its remarkable health-enhancing benefits. These effects encompass a wide range of properties, including antibacterial, antioxidant, anti-inflammatory, and anti-tumor activities. With the rapid advancements in chemical modification technology for oligosaccharides, many COS derivatives have been synthesized and investigated. These newly developed derivatives possess more stable chemical structures, improved biological activities, and find applications across a broader spectrum of fields. Given the recent interest in the chemical modification of COS, this comprehensive review seeks to consolidate knowledge regarding the preparation methods for COS derivatives, alongside discussions on their structural characterization. Additionally, various biological activities of COS derivatives have been discussed in detail. Lastly, the potential applications of COS derivatives in biomedicine have been reviewed and presented.
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