对称化
化学
手性(物理)
硅氢加成
对映选择合成
轴手性
立体化学
催化作用
立体选择性
组合化学
有机化学
手征对称破缺
物理
量子力学
夸克
Nambu–Jona Lasinio模型
作者
Changsheng Zhou,Yixin Liang,Ying Liu,Ming Huang,Ziwei Luo,Ke‐Fang Yang,Ze Li,Guoqiao Lai,Pinglu Zhang
标识
DOI:10.1021/acs.orglett.4c00292
摘要
Chiral spirocyclopropyl β-lactams are common motifs in bioactive compounds and pharmaceuticals. Here we disclose a diastereoselective and enantioselective hydroborylation and hydrosilylation of spirocyclopropenes, via a Cu-catalyzed desymmetrization strategy, for the rapid preparation of enantio-enriched spirocyclopropyl β-lactams. The efficient desymmetrization strategy allows the remote control of axial chirality, offering the borylated and silylated products bearing central, spiro, and axial chirality. The combination of multichiral elements would provide a novel motif for biological evaluation in potential drug discovery.
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