原肠化
生物
神经形成
解剖
细胞生物学
胚胎
形态发生
外胚层
胚胎发生
遗传学
基因
作者
Anna Popkova,Urška Andrenšek,Sophie Pagnotta,P. Ziherl,Matej Krajnc,Matteo Rauzi
标识
DOI:10.1016/j.devcel.2023.12.016
摘要
Epithelial furrowing is a fundamental morphogenetic process during gastrulation, neurulation, and body shaping. A furrow often results from a fold that propagates along a line. How fold formation and propagation are controlled and driven is poorly understood. To shed light on this, we study the formation of the cephalic furrow, a fold that runs along the embryo dorsal-ventral axis during Drosophila gastrulation and the developmental role of which is still unknown. We provide evidence of its function and show that epithelial furrowing is initiated by a group of cells. This cellular cluster works as a pacemaker, triggering a bidirectional morphogenetic wave powered by actomyosin contractions and sustained by de novo medial apex-to-apex cell adhesion. The pacemaker’s Cartesian position is under the crossed control of the anterior-posterior and dorsal-ventral gene patterning systems. Thus, furrow formation is driven by a mechanical trigger wave that travels under the control of a multidimensional genetic guide.
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