化学
立体选择性
仙磷
区域选择性
磷化氢
催化作用
配体(生物化学)
镍
选择性
组合化学
立体化学
药物化学
有机化学
钯
生物化学
受体
作者
Shutao Qi,Yunkai Hua,Liangkai Pan,Junfeng Yang,Junliang Zhang
标识
DOI:10.1002/cjoc.202300579
摘要
Comprehensive Summary Herein, we report nickel‐catalyzed cross‐coupling of gem ‐difluorinated cyclopropanes with boronic acids, providing the corresponding arylated 2‐fluoroallylic scaffolds. This approach used commercially available phosphine ligand Xantphos to obtain monofluorinated alkenes with high regioselectivity and Z ‐stereoselectivity. Mechanistic studies proposed a Ni(II)‐fluoroallyl pathway and excluded the radical pathway. Meanwhile, DFT study of the reductive elimination clarified the origin of the high linear selectivity.
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