化学
电泳剂
亲核细胞
试剂
区域选择性
恶嗪类
碳负离子
组合化学
钯
催化作用
有机化学
作者
Tao Ju,Ailing Lu,Yan Zhou,Gao Min,Jing Sun,Ying Han,Chao‐Guo Yan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-30
卷期号:25 (49): 8819-8823
标识
DOI:10.1021/acs.orglett.3c03407
摘要
Oxazines are an important class of compounds in oxazine ligands and medical chemistry. Here, we describe a linear-selective allylation of imines with allyl electrophiles via cross-electrophile coupling reactions, followed by cyclization with halogenated reagents, providing a new strategy to afford oxazine compounds with a tetrasubstituted carbon center. Mechanistic studies indicate that α-amino carbanion, generated by successive single-electron transfer processes, is a key intermediate for nucleophile attack on π-allylpalladium in photoredox/palladium catalysis.
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