生物
代谢组
怀孕
内分泌学
内科学
生理学
生物信息学
遗传学
代谢组学
医学
作者
Dainan Yu,Haifeng Wang,Chao Tong,Guang Lu,Gang Chen,Jiali Su,Lan Zhang,Wei Wang,Xiao Zhang,Jinglei Zhai,Yan Liu,Wenwu Ma,Kun Liang,Taoyan Liu,Yuefan Wang,Zhao Peng,Lanfang Luo,Ruoxuan Yu,Li Wei,Hongbo Qi,Hongmei Wang,Ng Shyh‐Chang
出处
期刊:Cell
[Elsevier]
日期:2024-02-01
卷期号:187 (3): 764-781.e14
标识
DOI:10.1016/j.cell.2023.11.043
摘要
Summary
Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this metabolic reprogramming remain poorly understood, especially in primates. Using cynomolgus monkeys, we constructed a comprehensive multi-tissue metabolome atlas, analyzing 273 samples from 23 maternal tissues during pregnancy. We discovered a decline in metabolic coupling between tissues as pregnancy progressed. Core metabolic pathways that were rewired during primate pregnancy included steroidogenesis, fatty acid metabolism, and arachidonic acid metabolism. Our atlas revealed 91 pregnancy-adaptive metabolites changing consistently across 23 tissues, whose roles we verified in human cell models and patient samples. Corticosterone and palmitoyl-carnitine regulated placental maturation and maternal tissue progenitors, respectively, with implications for maternal preeclampsia, diabetes, cardiac hypertrophy, and muscle and liver regeneration. Moreover, we found that corticosterone deficiency induced preeclampsia-like inflammation, indicating the atlas's potential clinical value. Overall, our multi-tissue metabolome atlas serves as a framework for elucidating the role of metabolic regulation in female health during pregnancy.
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