广告
阿法替尼
A549电池
对接(动物)
化学
IC50型
表皮生长因子受体
药理学
立体化学
阳性对照
组合化学
体外
受体
生物
生物化学
埃罗替尼
传统医学
医学
护理部
作者
Liang Liang Chi Liang Liang,Zhi qiang Cai Zhi qiang Cai,Bo Wang Bo Wang,Wei Qin,Y. Wang,Qiao Ren
标识
DOI:10.52568/001391/jcsp/45.06.2023
摘要
A series of 4-aminoquinazoline derivatives were designed and synthesized as epidermal growth factor receptor (EGFR) inhibitors in our group. The bioassay results showed all the target compounds possessed potential anti-tumor activities against on A549 and H1975 cell lines. The IC50 values of 8.35 (for A549) and 19.18 μM (for H1975) exhibited remarkable inhibitory activity of compound 7d, which were better compared to the positive control Afatinib (IC50 = 10.41 μM for A549, IC50 = 24.96 μM for H1975). In addition, the molecular docking and ADME prediction of compound 7d was carried out. The experimental results show the compound 7d is worth to further research and discuss.
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