某种肠道细菌
肠道菌群
微生物群
生物
脂质代谢
肠道微生物群
阿克曼西亚
益生菌
胆固醇
血脂谱
血脂
生理学
免疫学
细菌
内分泌学
生物信息学
乳酸菌
遗传学
作者
Ineta Kalniņa,Dita Gudrā,Ivars Silamiķelis,Kristīne Vīksne,Ance Roga,Edmunds Skinderskis,Dāvids Fridmanis,Jānis Kloviņš
标识
DOI:10.3390/microorganisms11112656
摘要
The gut microbiome is a versatile system regulating numerous aspects of host metabolism. Among other traits, variations in the composition of gut microbial communities are related to blood lipid patterns and hyperlipidaemia, yet inconsistent association patterns exist. This study aims to assess the relationships between the composition of the gut microbiome and variations in lipid profiles among healthy adults. This study used data and samples from 23 adult participants of a previously conducted dietary intervention study. Circulating lipid measurements and whole-metagenome sequences of the gut microbiome were derived from 180 blood and faecal samples collected from eight visits distributed across an 11-week study. Lipid-related variables explained approximately 4.5% of the variation in gut microbiome compositions, with higher effects observed for total cholesterol and high-density lipoproteins. Species from the genera Odoribacter, Anaerostipes, and Parabacteroides correlated with increased serum lipid levels, whereas probiotic species like Akkermansia muciniphila were more abundant among participants with healthier blood lipid profiles. An inverse correlation with serum cholesterol was also observed for Massilistercora timonensis, a player in regulating lipid turnover. The observed correlation patterns add to the growing evidence supporting the role of the gut microbiome as an essential regulator of host lipid metabolism.
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