言语记忆
扩大残疾状况量表
认知
工作记忆
医学
睡眠剥夺对认知功能的影响
物理医学与康复
物理疗法
心理学
多发性硬化
精神科
作者
Heena R. Manglani,Madhura Phansikar,Elizabeth Jean Duraney,Michael R. McKenna,Rosie Canter,Jacqueline Nicholas,Rebecca Andridge,Ruchika Shaurya Prakash
标识
DOI:10.1016/j.msard.2023.104963
摘要
Background Cognitive dysfunction is a pervasive symptom of multiple sclerosis (MS). Correlational evidence on the relationships between physical activity, sedentary behavior, and cognition has been mixed and limited to a few activity measures. The collinearity of accelerometry-based metrics has precluded an assessment of the full activity spectrum. Here, we aimed to examine the rich set of activity measures using analytic approaches suitable for collinear metrics. We investigated the combination of physical activity, sedentary, and clinicodemographic measures that explain the most variance in composite scores of working memory/processing speed, visual memory, and verbal memory. Methods We analyzed baseline accelerometry and neuropsychological data (n = 80) from a randomized controlled trial of pedometer tracking. Using partial least squares regression (PLSR), we built three models to predict latent scores on the three domains of cognition using 12 activity metrics, sex, education, and Expanded Disability Status Scale (EDSS) scores. Significance was assessed using linear regression models with model component scores as predictors and cognitive composites as outcomes. Results The latent component was significant for working memory/processing speed but was not significant for visual memory and verbal memory after Bonferroni correction. Working memory/processing speed was positively associated with average kilocalories, moderate-to-vigorous physical activity (MVPA), steps, and sex (i.e., higher scores in males) and negatively related to duration of long sedentary bouts and EDSS. Conclusions These findings suggest that increasing overall energy expenditure through walking and MVPA, while decreasing prolonged sedentary time may positively benefit working memory/processing speed in people with MS. Trial Registration This RCT #NCT03244696 was registered on Clinicaltrials.gov (https://www.clinicaltrials.gov/ct2/show/NCT03244696).
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