泛素
修剪
肝细胞癌
自噬
蛋白酶体
生物
肝癌
癌症研究
蛋白质降解
泛素连接酶
细胞生物学
生物信息学
细胞凋亡
基因
遗传学
计算机科学
操作系统
作者
Jie Zhang,Yuting Zhou,Feng Jiao,Xuanfu Xu,Jianye Wu,Chuanyong Guo
标识
DOI:10.1016/j.biopha.2023.115538
摘要
Tripartite motif (TRIM) family is assigned to RING-finger-containing ligases harboring the largest number of proteins in E3 ubiquitin ligating enzymes. E3 ubiquitin ligases target the specific substrate for proteasomal degradation via the ubiquitin-proteasome system (UPS), which seems to be a more effective and direct strategy for tumor therapy. Recent advances have demonstrated that TRIM genes associate with the occurrence and progression of hepatocellular carcinoma (HCC). TRIMs trigger or inhibit multiple biological activities like proliferation, apoptosis, metastasis, ferroptosis and autophagy in HCC dependent on its highly conserved yet diverse structures. Remarkably, autophagy is another proteolytic pathway for intracellular protein degradation and TRIM proteins may help to delineate the interaction between the two proteolytic systems. In depth research on the precise molecular mechanisms of TRIM family will allow for targeting TRIM in HCC treatment. We also highlight several potential directions warranted further development associated with TRIM family to provide bright insight into its translational values in hepatocellular carcinoma.
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