Carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis

医学 溃疡性结肠炎 疾病 炎症性肠病 结直肠癌 癌胚抗原 发育不良 发病机制 癌症 内科学 结肠切除术 结肠炎 免疫学 胃肠病学
作者
Qianqian Wang,Cheng Zuo,Rui Zhang,Limei Zhu
出处
期刊:World Journal of Gastrointestinal Oncology [Baishideng Publishing Group Co (World Journal of Gastrointestinal Oncology)]
卷期号:15 (8): 1475-1485
标识
DOI:10.4251/wjgo.v15.i8.1475
摘要

Colitis-associated colorectal cancer (CAC) is defined as a specific cluster of colorectal cancers that develop as a result of prolonged colitis in patients with inflammatory bowel disease (IBD). Patients with IBD, including ulcerative colitis and Crohn’s disease, are known to have an increased risk of developing CAC. Although the incidence of CAC has significantly decreased over the past few decades, individuals with CAC have increased mortality compared to individuals with sporadic colorectal cancer, and the incidence of CAC increases with duration. Chronic inflammation is generally recognized as a major contributor to the pathogenesis of CAC. CAC has been shown to progress from colitis to dysplasia and finally to carcinoma. Accumulating evidence suggests that multiple immune-mediated pathways, DNA damage pathways, and pathogens are involved in the pathogenesis of CAC. Over the past decade, there has been an increasing effort to develop clinical approaches that could help improve outcomes for CAC patients. Colonoscopic surveillance plays an important role in reducing the risk of advanced and interval cancers. It is generally recommended that CAC patients undergo endoscopic removal or colectomy. This review summarizes the current understanding of CAC, particularly its epidemiology, mechanisms, and management. It focuses on the mechanisms that contribute to the development of CAC, covering advances in genomics, immunology, and the microbiome; presents evidence for management strategies, including endoscopy and colectomy; and discusses new strategies to interfere with the process and development of CAC. These scientific findings will pave the way for the management of CAC in the near future.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
l老王完成签到 ,获得积分10
2秒前
会撒娇的蓝天完成签到 ,获得积分10
3秒前
gogogo发布了新的文献求助10
7秒前
Hiker给Hiker的求助进行了留言
10秒前
端庄豌豆完成签到 ,获得积分10
12秒前
18秒前
oo完成签到 ,获得积分10
22秒前
长安发布了新的文献求助10
23秒前
Kevin应助长安采纳,获得20
28秒前
长安完成签到,获得积分10
40秒前
甜蜜发带完成签到 ,获得积分10
41秒前
Lilycat完成签到 ,获得积分10
41秒前
jasmine完成签到 ,获得积分10
46秒前
Hiker完成签到,获得积分10
58秒前
奶糖喵完成签到 ,获得积分10
1分钟前
nanonamo完成签到,获得积分10
1分钟前
伶俐绿海完成签到 ,获得积分10
1分钟前
Steven完成签到,获得积分10
1分钟前
倪小呆完成签到 ,获得积分10
1分钟前
liuq完成签到,获得积分20
1分钟前
mailgo完成签到,获得积分10
1分钟前
金生六完成签到 ,获得积分10
1分钟前
所所应助liuq采纳,获得10
2分钟前
淡淡菠萝完成签到 ,获得积分10
2分钟前
2分钟前
踏实手套完成签到 ,获得积分10
2分钟前
ashley325完成签到 ,获得积分10
2分钟前
liuq发布了新的文献求助10
2分钟前
但大图完成签到 ,获得积分10
2分钟前
chen完成签到,获得积分10
2分钟前
小明完成签到,获得积分10
2分钟前
2分钟前
知行合一完成签到 ,获得积分10
2分钟前
崔宁宁完成签到 ,获得积分10
2分钟前
陈荣完成签到 ,获得积分10
2分钟前
gogogo完成签到,获得积分10
2分钟前
mgqqlwq发布了新的文献求助10
3分钟前
HS完成签到,获得积分10
3分钟前
yes完成签到 ,获得积分10
3分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Python Programming for Linguistics and Digital Humanities: Applications for Text-Focused Fields 500
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2546110
求助须知:如何正确求助?哪些是违规求助? 2175672
关于积分的说明 5600244
捐赠科研通 1896399
什么是DOI,文献DOI怎么找? 946268
版权声明 565379
科研通“疑难数据库(出版商)”最低求助积分说明 503557