亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Associations of Plasma Omega-3 Fatty Acids With Progression and Survival in Pulmonary Fibrosis

医学 二十碳五烯酸 内科学 六烯酸 危险系数 胃肠病学 肺纤维化 比例危险模型 特发性肺纤维化 纤维化 队列 扩散能力 脂肪酸 多不饱和脂肪酸 置信区间 化学 生物化学 肺功能
作者
John S. Kim,Shwu‐Fan Ma,Z. Jennie,Yong Huang,Catherine A. Bonham,Justin M. Oldham,Ayodeji Adegunsoye,Mary E. Strek,Kevin R. Flaherty,Emma Strickland,Inemesit Udofia,Joshua J. Mooney,Shrestha Ghosh,Krishnarao Maddipati,Imre Noth
出处
期刊:Chest [Elsevier BV]
卷期号:165 (3): 621-631 被引量:6
标识
DOI:10.1016/j.chest.2023.09.035
摘要

Preclinical experiments suggest protective effects of omega-3 fatty acids and their metabolites in lung injury and fibrosis. Whether higher intake of omega-3 fatty acids is associated with disease progression and survival in humans with pulmonary fibrosis is unknown.What are the associations of plasma omega-3 fatty acid levels (a validated marker of omega-3 nutritional intake) with disease progression and transplant-free survival in pulmonary fibrosis?Omega-3 fatty acid levels were measured from plasma samples of patients with clinically diagnosed pulmonary fibrosis from the Pulmonary Fibrosis Foundation Patient Registry (n = 150), University of Virginia (n = 58), and University of Chicago (n = 101) cohorts. The N-3 index (docosahexaenoic acid + eicosapentaenoic acid) was the primary exposure variable of interest. Linear-mixed effects models with random intercept and slope were used to examine associations of plasma omega-3 fatty acid levels with changes in FVC and diffusing capacity for carbon monoxide over a period of 12 months. Cox proportional hazards models were used to examine transplant-free survival. Stratified analyses by telomere length were performed in the University of Chicago cohort.Most of the cohort were patients with idiopathic pulmonary fibrosis (88%) and male patients (74%). One-unit increment in log-transformed N-3 index plasma level was associated with a change in diffusing capacity for carbon monoxide of 1.43 mL/min/mm Hg per 12 months (95% CI, 0.46-2.41) and a hazard ratio for transplant-free survival of 0.44 (95% CI, 0.24-0.83). Cardiovascular disease history, smoking, and antifibrotic usage did not significantly modify associations. Omega-3 fatty acid levels were not significantly associated with changes in FVC. Higher eicosapentaenoic acid plasma levels were associated with longer transplant-free survival among University of Chicago participants with shorter telomere length (P value for interaction = .02).Further research is needed to investigate underlying biological mechanisms and whether omega-3 fatty acids are a potential disease-modifying therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
生如夏花完成签到 ,获得积分10
3秒前
rpe完成签到,获得积分10
11秒前
科研通AI5应助垚祎采纳,获得30
25秒前
40秒前
垚祎发布了新的文献求助30
50秒前
科研通AI2S应助科研通管家采纳,获得20
57秒前
NexusExplorer应助余书文采纳,获得10
1分钟前
lixuebin完成签到 ,获得积分10
1分钟前
李健的小迷弟应助垚祎采纳,获得10
1分钟前
1分钟前
余书文完成签到,获得积分20
1分钟前
1分钟前
余书文发布了新的文献求助10
1分钟前
1分钟前
垚祎发布了新的文献求助10
1分钟前
woxinyouyou完成签到,获得积分0
2分钟前
JamesPei应助垚祎采纳,获得10
2分钟前
2分钟前
垚祎发布了新的文献求助10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
CipherSage应助科研通管家采纳,获得10
2分钟前
乐乐应助垚祎采纳,获得10
3分钟前
3分钟前
垚祎发布了新的文献求助10
3分钟前
小海完成签到,获得积分10
4分钟前
alexlpb完成签到,获得积分0
4分钟前
赘婿应助垚祎采纳,获得10
4分钟前
4分钟前
垚祎发布了新的文献求助10
4分钟前
4分钟前
李健应助垚祎采纳,获得10
5分钟前
5分钟前
垚祎发布了新的文献求助10
5分钟前
xyzpp发布了新的文献求助100
5分钟前
Owen应助垚祎采纳,获得10
6分钟前
6分钟前
垚祎发布了新的文献求助10
6分钟前
20240901完成签到,获得积分10
6分钟前
酷波er应助科研通管家采纳,获得10
6分钟前
香蕉觅云应助垚祎采纳,获得10
6分钟前
高分求助中
中华人民共和国出版史料 4 1000
Applied Survey Data Analysis (第三版, 2025) 800
Narcissistic Personality Disorder 700
Assessing and Diagnosing Young Children with Neurodevelopmental Disorders (2nd Edition) 700
Handbook of Experimental Social Psychology 500
The Martian climate revisited: atmosphere and environment of a desert planet 500
建国初期十七年翻译活动的实证研究. 建国初期十七年翻译活动的实证研究 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3845540
求助须知:如何正确求助?哪些是违规求助? 3387824
关于积分的说明 10550641
捐赠科研通 3108452
什么是DOI,文献DOI怎么找? 1712776
邀请新用户注册赠送积分活动 824505
科研通“疑难数据库(出版商)”最低求助积分说明 774877