Remission of prediabetes via lifestyle intervention

In this issue of The Lancet Diabetes & Endocrinology, a post-hoc analysis of the Prediabetes Lifestyle Intervention Study (PLIS) by Sandforth and colleagues1 provides insights into the physiological mechanisms that govern remission to normal glucose regulation (NGR) from prediabetes. Participants were classified as responders, defined as people who returned to typical fasting plasma glucose (FPG), typical glucose tolerance, and HbA1c less than 39 mmol/mol (5·7%) after 12 months of intervention, or non-responders, defined as people who had FPG, post-challenge glucose, or HbA1c higher than these thresholds.