小胶质细胞
细胞
清脆的
星形胶质细胞
计算生物学
生物
细胞生物学
神经科学
免疫学
遗传学
基因
中枢神经系统
炎症
作者
Caitlin M. Aamodt,Nathan E. Lewis
出处
期刊:Cell systems
[Elsevier]
日期:2023-06-01
卷期号:14 (6): 428-429
被引量:1
标识
DOI:10.1016/j.cels.2023.05.006
摘要
A new method developed by Francisco Quintana's group, systematic perturbation of encapsulated associated cells followed by sequencing (SPEAC-seq), applies a CRISPR screen to co-cultured interacting cells to identify the ligands mediating cell-cell communication. Using this approach, the authors discover the molecular basis of a microglia-astrocyte feedback loop that suppresses neuroinflammatory disease.
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