丙二醛
超氧化物歧化酶
肝损伤
过氧化氢酶
化学
谷胱甘肽过氧化物酶
药理学
乳酸脱氢酶
醇脱氢酶
乙醛
谷胱甘肽
生物化学
传统医学
抗氧化剂
乙醇
医学
酶
作者
Yuan Gao,Zihao Zong,Wei Xia,Xiangjun Fang,Ruiling Liu,Wei Wu,Honglei Mu,Yanchao Han,Shaobo Xiao,Haiyan Gao,Hangjun Chen
摘要
Abstract In this study, the hepatoprotective effect of alkali extract (NE) of water bamboo shoot (WBS) against acute alcoholic liver injury (ALI) in mice was evaluated, and its underlying mechanisms were explored. Animal experiment demonstrated that NE exhibited hepatoprotective effect on alcoholic intake‐induced ALI via significantly enhancing the hepatic activities of alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and catalase (CAT), whereas significantly attenuated hepatic levels of malondialdehyde (MDA), interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α). The potential molecular mechanism and bioactive compounds of NE against ALI were explored by bioinformatics analysis and isosinensetin was found to be the major bioactive compounds in NE against ALI. The western blot analysis showed that NE inhibited phosphorylation of p65 and IκBα to suppress the NF‐κB pathway. Overall our result indicated that WBS possesses potential hepatoprotective effects against ALI.
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