Negative Correlation Between Secreted Phosphoprotein 1 and the Treg/Th17 Ratio in Non-Valvular Atrial Fibrillation

Our findings suggest that elevated SPP1 levels disrupt the Treg/Th17 cell balance in NVAF patients, promoting inflammation and fibrosis. These findings indicate that SPP1 represents a promising therapeutic target for the prevention and management of NVAF.