Jellyfish collagen peptides: anti-aging mechanism and potential application in skincare

Aging is a universal biological process involving cellular and molecular changes that lead to various age-related issues. Skin aging, both natural and exogenous factors, is a prominent manifestation of this process. Oligopeptides, particularly those derived from marine sources such as jellyfish collagen polypeptides, have demonstrated significantly potential in anti-aging applications due to their diverse biological activities. This study systematically investigated the anti-aging effects of jellyfish collagen peptides on skin using multiple methods, including cytotoxicity assessment, in vitro cell experiments, and evaluations of free radical scavenging, anti-wrinkle effects, collagen proliferation, cytokine inhibition, and protection against cellular damage. The findings indicate that jellyfish collagen peptides can delay skin aging through multiple mechanisms, providing valuable insights for the development of anti-aging skincare products. • Jellyfish peptide is non-toxic and biocompatible with human skin cells. • Jellyfish peptide inhibits the accumulation of reactive oxygen species. • Jellyfish peptide has the protective role against UV-induced damage and potential in reducing skin wrinkles. • Jellyfish peptide up-regulate the expression of both type I and type III collagen in human fibroblasts.