PH20-modified exosomes loaded curcumin inhibit desmoplastic breast cancer by breaking extracellular matrix barrier and normalizing cancer-associated fibroblasts

T cells infiltration, contributed to effective cytotoxic inhibition on cancer cells. This green synthesized biocompatible nanoplatform offers a promising dual therapeutic strategy for remodeling desmoplastic TME and inhibiting tumor progression with effective drug delivery for improved TNBC therapeutic outcomes.