Cerium Oxide-Modified Pd Nanosheets Encapsulated by Red Blood Cell Membranes with High-Efficiency RONS Scavenging for Depression Treatment

Depression, a common and high-morbidity mental illness, can cause severe physical and psychiatric disorder. Recently, elevated levels of reactive oxygen and nitrogen species (RONS) have been recognized as a potential pathogenesis of depression. Unfortunately, available therapies provide limited outcomes in treating RONS-related depression symptoms. In addition, the low blood-brain barrier (BBB) penetration efficiency of some drugs is another major barrier to depression treatment. This study developed cerium oxide-modified Pd (Pd-CeO