阿霉素
细胞凋亡
基因敲除
癌症研究
下调和上调
肿瘤坏死因子α
心肌病
医学
药理学
生物
内科学
心力衰竭
化疗
生物化学
基因
作者
Lin Xie,Fei Xue,Cheng Cheng,Wenhai Sui,Jie Zhang,Linlin Meng,Yue Lu,Wenjing Xiong,Peili Bu,Feng Xu,Xiaoyan Yu,Bo Xi,Lin Zhong,Jian-Min Yang,Cheng Zhang,Yun Zhang
标识
DOI：10.1038/s41392-024-01977-z
摘要
The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear. This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 may ameliorate doxorubicin-induced cardiomyopathy. C57BL/6J mice were intraperitoneally injected with a cumulative dose of doxorubicin to induce cardiomyopathy. Cardiomyocyte-specific ADAM17-knockout (A17
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