In Vitro Identification of Oridonin hybrids as Potential Anti-TNBC Agents inducing Cell Cycle Arrest and Apoptosis by Regulation of p21, γH2AX and Cleaved PARP

Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.