New revolution for quality control of TCM in industry 4.0: Focus on artificial intelligence and bioinformatics

Quality controllability of traditional Chinese medicine (TCM) is the cornerstone for safety and efficacy. Under Industry 4.0, what are the great transformations of quality control for TCM in global is the current urgent concern. Heren, we foresight focus on artificial intelligence and bioinformatics perspectives to reveal the progress of TCM quality control in intelligent era. Integrating the complexity, technological innovations, and outputs, the unique advantages of both directions in quality control of TCM are presented. Furthermore, we also provide insightful analyses of shortcomings and propose potential specialized solutions. In new quality productive forces, important directions in future cross-cutting areas of high-quality TCM formation, smart testing, and regulatory science are prospectively and systematically outlooked. This review dedicated to insight into intelligent of TCM quality control. It has profound significance to guide TCM internationalization. • Artificial intelligence advances TCM quality control innovations and applications in industry 4.0. • Bioinformatics highlights the utility characteristics of quality indicators in TCM. • Artificial intelligence and bioinformatics interaction to enhance TCM quality control. • Shortcomings and countermeasures are foregrounded in the quality control of TCM.