Abstract Despite the progresses made over the recent years on heart transplantation, there are few data in literature about mitral regurgitation in transplated hearts. We report a case of a 62-year-old Italian man who presented dyspnea for mild exercise two years after orthotopic heart transplantation. He was found to have sever mitral regurgitation and underwent a successful implantation of a double MitraClip with the reduction of the mitral regurgitation and improvement of the symptoms. Two months later, he was still doing well and a repeted echocardiogram showed good results with only residual mild aortic insufficiency. We found few previously reported cases using the MitraClip to treat mitral regurgitation in adult cardiac transplant patients.