烟酰胺单核苷酸
代谢工程
生物化学
NAD+激酶
生物合成
化学
代谢途径
烟酰胺
计算生物学
酶
生物
烟酰胺腺嘌呤二核苷酸
作者
Yuxian Chen,Churan Zhou,Jianzhong Huang,Yong Tao,Chongrong Ke,Xinwei Yang
出处
期刊:PubMed
日期:2023-02-25
卷期号:39 (2): 516-536
被引量:1
标识
DOI:10.13345/j.cjb.220880
摘要
Nicotinamide mononucleotide (NMN) is one of the key precursors of coenzyme Ⅰ (NAD+). NMN exists widely in a variety of organisms, and β isomer is its active form. Studies have shown that β-NMN plays a key role in a variety of physiological and metabolic processes. As a potential active substance in anti-aging and improving degenerative and metabolic diseases, the application value of β-NMN has been deeply explored, and it is imminent to achieve large-scale production. Biosynthesis has become the preferred method to synthesize β-NMN because of its high stereoselectivity, mild reaction conditions, and fewer by-products. This paper reviews the physiological activity, chemical synthesis as well as biosynthesis of β-NMN, highlighting the metabolic pathways involved in biosynthesis. This review aims to explore the potential of improving the production strategy of β-NMN by using synthetic biology and provide a theoretical basis for the research of metabolic pathways as well as efficient production of β-NMN.
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