材料科学
纳米纤维
两亲性
静电纺丝
PLGA公司
伤口愈合
生物相容性
抗菌活性
纳米技术
复合材料
纳米颗粒
医学
外科
细菌
生物
聚合物
遗传学
共聚物
冶金
作者
Yupeng Shi,Mengyang Zhou,Shuo Zhao,Haotian Li,Wenhao Wang,Jingliang Cheng,Lin Jin,Yifei Wang
标识
DOI:10.1016/j.matdes.2023.111778
摘要
Prevention of bacterial infection and control of inflammatory responses play critical roles in wound healing. Wound dressing loaded with antibacterial or anti-inflammatory drugs/molecules is one of the feasible routes in clinical applications. Nonetheless, effective and controllable drug release remains challenging. Herein, by electrospinning polyvinyl alcohol (PVA), polylactic acid-glycolic acid (PLGA) with copper sulfide nanoparticles (CuS NPs) and two model drugs, namely antibacterial drugs (mupirocin, M) and anti-inflammatory drugs (valsartan, V), an operable wound-healing patch consist of amphiphilic Janus nanofiber membrane (PLGAV-CuS/PVAM) was prepared which was used to controllable gradient drug release in wound healing. Janus nanofiber membrane shows typical amphiphilic characteristics, with low biological toxicity and good biocompatibility. In vitro experiments showed that the nanofiber membrane could slowly and continuously release mupirocin in a hydrophilic environment for antibacterial purposes. In addition, the excellent photothermal effect of PLGAV CuS/PVAM can regulate the release rate of the anti-inflammatory drug valsartan, effectively reduce the inflammatory reaction in the wound healing process, and also show enhanced bacteriostasis efficiency (96.3% of Escherichia coli and 97.8% of Staphylococcus aureus). The prepared patches exhibited excellent antibacterial, anti-inflammatory, and sustained-release effects, which is of great significance for board the avenue of nanofiber in the biomedical field.
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