信使核糖核酸
体内分布
核酸
化学
免疫系统
病毒学
医学
生物化学
免疫学
体外
基因
作者
Jinrong Long,Changxiao Yu,Honglei Zhang,Yiming Cao,Ye Sang,Haitao Lü,Zhen Zhang,Xin Wang,Huanyu Wang,Guohe Song,Jing Yang,Shengqi Wang
标识
DOI:10.1002/adhm.202202590
摘要
Abstract mRNA‐based therapy has emerged as the most promising nucleic acid therapy in the fight against COVID‐19. However, a safe and efficacious systemic delivery remains a challenge for mRNA therapy. Lipid nanoparticles (LNPs) are currently widely used in mRNA delivery vehicles. Here, a series of ionizable LNPs is rationally designed. YK009‐LNP is an optimal delivery platform to carry mRNA. YK009‐LNP exhibits higher mRNA delivery efficiency, a more favorable biodistribution pattern, and better safety than the approved MC3‐LNP. In addition, mRNA encoding severe acute respiratory syndrome coronavirus 2 Omicron receptor binding domain protein is synthesized and intramuscular administration of mice with YK009‐LNP‐Omicron mRNA induces a robust immune response and immune protective effect. A novel mRNA delivery vehicle with more powerful delivery efficiency and better safety than the approved LNPs is provided here.
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