Homeostatic Control of Neuronal Activity

For healthy brain functioning, it is crucial that neuronal networks do not become hyperactive, but also, that they remain excitable. Homeostatic mechanisms ensure that neuronal activity remains within a functional range. How does that work? In this chapter, we will explore homeostatic control of neuronal activity. We will start by introducing the basics of neuronal communication to establish what makes a neuron excitable. Then, we will learn how neurons are able to tune their own excitability, which is called homeostatic intrinsic plasticity. Next, we will discuss the ability of neurons to tune the strength of their connections to other neurons. This is called homeostatic synaptic plasticity and involves synaptic scaling, the up- and downregulation of receptors, and the control of neurotransmitter release. Finally, we will review the role of glia in neuronal network homeostasis and discuss disorders where the homeostatic control of neuronal activity is compromised.