化学
磷化氢
钯
催化作用
氧化膦
磷
选择性
有机化学
组合化学
作者
Hua Huang,Yonghong Wu,Luyao Han,Jian Lü,Zhuo‐Zhuo Zhang,Xiang Zhang,Bo Han,Wei Huang,Junlong Li
摘要
Allylphosphine oxide compounds are important building blocks with broad applications in organic synthesis and pharmaceutical science. Herein, we report an unprecedented palladium-catalyzed allylation of phosphine oxides with vinylethylene carbonates, producing various phosphorus allyl alcohols in excellent yields with high Z-selectivity. In addition, gram-scale synthesis and further functional group transformations demonstrate the practical utility of this synthetic method.
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