细胞周期蛋白依赖激酶8
癌变
调解人
癌症研究
转录因子
肿瘤进展
抄写(语言学)
生物
信号转导
基因
细胞生物学
遗传学
Notch信号通路
语言学
哲学
作者
Xiaonan Yin,Zhilong He,Kun Chen,Kang Ouyang,Changxuan Yang,Jianjun Li,Hailin Tang,Manbo Cai
标识
DOI:10.3389/fphar.2024.1386929
摘要
CDK8 is an important member of the cyclin-dependent kinase family associated with transcription and acts as a key "molecular switch" in the Mediator complex. CDK8 regulates gene expression by phosphorylating transcription factors and can control the transcription process through Mediator complex. Previous studies confirmed that CDK8 is an important oncogenic factor, making it a potential tumor biomarker and a promising target for tumor therapy. However, CDK8 has also been confirmed to be a tumor suppressor, indicating that it not only promotes the development of tumors but may also be involved in tumor suppression. Therefore, the dual role of CDK8 in the process of tumor development is worth further exploration and summary. This comprehensive review delves into the intricate involvement of CDK8 in transcription-related processes, as well as its role in signaling pathways related to tumorigenesis, with a focus on its critical part in driving cancer progression.
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