血管生成
后脑
生物
病理
视网膜
血管
新生血管
伤口愈合
神经科学
细胞生物学
胚胎
癌症研究
医学
免疫学
内分泌学
作者
Alessandro Fantin,Christiana Ruhrberg
出处
期刊:Methods in molecular biology
日期:2022-01-01
卷期号:: 275-287
标识
DOI:10.1007/978-1-0716-2217-9_20
摘要
Angiogenesis, the growth of new blood vessels from pre-existing ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining and analysis.
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