A Method for Treating Complications Developed Following Countour Correction with Calcium Hydroxylaptite-based Filler.

Fillers based on calcium hydroxyapatite (CaHA) have become popular for the correction of involutive skin changes. However, if the filler injection technique is violated, undesirable events can occur in the skin, the treatment of which is complicated by the lack of a specific antidote to CaHA.In this study, we aimed to evaluate the effectiveness of a combined method that includes a course of ultraphonophoresis of collagenase and diadynamophoresis of sodium thiosulfate (Na2S2O3) for the treatment of complications developed after contour correction with CaHA-based fillers.The study included 37 women aged 47.2±5.9 years old with a complication developed after the superficial injection of a CaHA-based filler localized in the facial area. The patients were divided into three groups; Group I received a course of ultraphonophoresis of collagenase (Collalysin 1000 CU); Group II received a course of diadynamophoresis of 30% Na2S2O3; and Group III received a combined treatment.A combined course (Group III) had a significant effect expressed as a reduction of contouration, gel visualization, local edema, and neuropathy, as well as a stabilized psychoemotional condition of patients. This treatment complex significantly accelerates the biodegradation of the filler and exerts a restructuring effect.The application of this combined treatment course in patients with complications following the superficial injection of CaHA-based filler appears to be a highly effective treatment method, which was confirmed by the resolution of clinical symptoms, accelerated drug biodegradation, and an increase in the patients' quality of life.