光热治疗
青光眼
生物相容性
泡(药)
青光眼手术
抗代谢物
纤维化
眼内炎
药物输送
眼压
小梁切除术
医学
眼科
外科
化学
化疗
病理
材料科学
纳米技术
有机化学
作者
Yanan Wang,Zikang Xu,Wenchi Li,Wei Wei,Mengqi Qin,Qun Li,Xuexia Liu,Xu Zhang,Xiaolei Wang
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:10 (5): 1281-1291
被引量:4
摘要
Excessive fibrosis is the major factor in the failure of glaucoma filtration surgery. So far, the dominant approach for inhibiting fibrosis is the use of an antimetabolite drug, but the complications it causes, such as filtering bleb leakage, bacterial endophthalmitis and ocular hypotony, are also inevitable. Herein, a multifunctional anti-scarring platform (PVA@rGO-Ag/5-Fu) integrated with outstanding photothermal, antibacterial and drug delivery abilities is developed. PVA@rGO-Ag shows favorable biocompatibility as well as an accurate regional photothermal killing ability on both conjunctival fibroblasts and bacteria under 808 nm near-infrared (NIR) irradiation. Furthermore, PVA@rGO-Ag/5-Fu improves bleb survival rates and results in the satisfactory reduction of intraocular pressure (IOP) by decreasing the fibrous reaction in vivo. In summary, PVA@rGO-Ag/5-Fu has promising potential as an efficacious and safe anti-scarring agent for filtering surgery.
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