脂解
脂肪生成
脂肪生成
肥胖
内科学
内分泌学
脂质代谢
化学
脂肪组织
生物
医学
作者
Soo‐Jeung Park,Jong-Lae Kim,Mi-Ryeong Park,Jong Wook Lee,Ok‐Kyung Kim,Jeongmin Lee
标识
DOI:10.1016/j.jff.2022.104951
摘要
This study aimed at evaluating whether Indian gooseberry (IG), barley sprout (BP), and their mixture (IGBP) could prevent obesity in vivo and be used as an anti-obesity functional food. We confirmed the detection of ellagic acid and saponarin, which are anti-obesity active components, through HPLC analysis of IGBP. C57BL/6J mice were fed a 60% high-fat diet supplemented with IGBP for 15 weeks, and then various analyzes (micro-CT imaging, blood analysis, H&E staining, and western blot) were performed. The IGBP mixture reduced the weight gain, WAT weight, serum lipid levels, as well as the systemic, subcutaneous, and visceral WAT adipose mass and lipid size in high-fat diet-induced mice. In addition, we found that the IGBP mixture inhibited the lipid synthesis, promoted the lipolysis, and modulated energy metabolism and diabetes-related blood markers. Therefore, IGBP mixture might potentially control the obesity and obesity-related diabetes, might be a useful as a functional food.
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