上睑下垂
坏死性下垂
程序性细胞死亡
炎症
细胞生物学
细胞凋亡
半胱氨酸蛋白酶
细胞
半胱氨酸蛋白酶1
生物
自噬
免疫学
遗传学
作者
Betsaida Bibo-Verdugo,Guy S. Salvesen
标识
DOI:10.1016/j.mam.2022.101085
摘要
Regulated cell death is defined as genetically encoded pathways that lead towards the demise of cells. In mammals, cell demise can be either inflammatory or non-inflammatory, depending on whether the mechanism of death results in cell rupture or not. Inflammatory cell death can lead towards acute and chronic disease. Therefore, it becomes important to distinguish the mechanisms that result in these different inflammatory cell death outcomes. Apoptosis is a non-inflammatory form of cell death where cells resist rupture. In contrast, pyroptosis and necroptosis are inflammatory forms of cell death principally because of release of pro-inflammatory mediators from cells undergoing lysis. This review focusses on the mechanisms of these different cell death outcomes with specific emphasis on the caspase family of proteolytic enzymes.
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